Year 2020 Vol. 28 No 4

REVIEWS

R.E. KALININ, I.A. SUCHKOV, E.A. KLIMENTOVA, A.A. EGOROV

TO THE QUESTION OF THE ROLE OF APOPTOSIS IN THE DEVELOPMENT OF ATHEROSCLEROSIS AND RESTENOSIS OF THE RECONSTRUCTION ZONE

Ryazan State Medical University, Ryazan,
The Russian Federation

Apoptosis is a model of genetically programmed cell death and the main mechanism that allows to remove the unwanted, old or damaged cells. In both physiological and pathophysiological conditions, various factors, including mechanical forces, reactive oxygen and nitrogen forms, cytokines, oxidized lipoproteins can affect vascular cell apoptosis. The signaling pathway of Fas / Fas- ligand / caspase death, the Bcl-2 / mitochondria family of proteins, the p53 tumor suppression gene, and the c-myc protooncogene can be activated in atherosclerotic lesions and mediate cell death during the development of atherosclerosis. Abnormal expression apoptosis-regulating genes and their dysfunction can weaken or accelerate apoptosis of vascular cells and affect the integrity and stability of atherosclerotic plaques. Further findings of the mechanism that regulates apoptosis can help develop a new treatment strategy for atherosclerosis and its main complication, restenosis of the reconstruction zone. At present, the role of apoptosis indicators in the development of atherosclerosis and its main complications remains unclear. Further study of this problem is required for a deeper understanding of atherosclerosis pathogenesis and restenosis of the reconstruction zone and the development of effective treatment methods.

Keywords: apoptosis, restenosis, atherosclerosis, Bcl-2 proteins, caspases
p. 418-427 of the original issue
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Address for correspondence:
390026, Russian Federation, Ryazan,
Vysokovoltnaya str. 9,
Ryazan State Medical University,
the Department of Cardiovascular,
Endovascular, Operative Surgery
and Topographic Anatomy
tel. +7 4912 46-08-03,
e-mail: Suchkov_med@mail.ru
Suchkov Igor A.
Information about the authors:
Kalinin Roman E., MD, Professor, Rector, Head of the Department of Cardiovascular, Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University, Ryazan, Russian Federation.
https://orcid.org/0000-0002-0817-9573
Suchkov Igor A., MD, Professor, Vice-Rector for Research and Innovative Development, Professor of the Departmentr of Cardiovascular, Endovascular, Operative Surgery And Topographic Anatomy, Ryazan State Medical University, Ryazan, Russian Federation.
https://orcid.org/0000-0002-1292-5452
Klimentova mma A., Post-Graduate Student of the Department of Cardiovascular, Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University, Ryazan, Russian Federation.
https://orcid.org/0000-0003-4855-9068
Egorov Andrei A., PhD, Associate Professor of the Departmentr of cardiovascular, endovascular, operative surgery and topographic anatomy, Ryazan State Medical University, Ryazan, Russian Federation.
https://orcid.org/0000-0003-0768-7602
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