Year 2020 Vol. 28 No 4




Mogilev Regional Hospital 1, Mogilev,
Vitebsk State Medical University 1, 2, Vitebsk,
The Republic of Belarus

Objective. To evaluate efficiency of bupivacaine and levobupivacaine for spinal anesthesia for lower limb surgery.
Methods. Anesthesia indicates in patients undergoing operations on the hip joint, thigh, knee joint. Patients were randomly divided into two groups: in group 1 (1B) spinal anaesthesia with 0.5% bupivacaine 3 ml: (38 patients); in group 2 (2L) 0.5% levobupivacaine 3 ml (38 patients) was performed. Intrathecal administrations were performed with Pencil point needle (24G or 25G caliber) into the intervertebral space L3-L4. Spinal puncture was performed in sitting position on the table. The primary endpoint was the need switching from one drug to another type of analgesia, or the need for additional use of narcotic analgesics, or the use of local anesthesia at the onset or during surgery.
Results. During surgery in 6 patients (15.7%) of group 2L, there was a need to relieve pain by narcotic analgesics (fentanyl) intraoperatively or using local anesthesia. The reliable differences between the groups regarding the need for additional intraoperative analgesia were obtained: p <0.05.
All patients in group 1B developed a complete sensory block within 4 (3; 5) min. In group 2L, the full sensory block developed in 34 patients (89.4%) within 9 (5; 14) minutes; statistically significant differences between the groups were obtained, p <0.05 (p = 0.000001).
The duration of the analgesia period between the groups did not statistically differ and amounted to 242 (212; 270) min in the 1B group, 250 (204; 288) min. in the 2L group, p>0.05.
Conclusion. The research results demonstrated that levobupivacaine has been found to be efficacious (84,3%) compared with bupivacaine in the case of intrathecal administration (equal doses and quantity of both drugs).
Further studies with a large number of patients are necessary in order to determine whether levobupivacaine has been to be equally efficacious as bupivacaine.

Keywords: spinal anesthesia, levobupivacaine, bupivacaine, intrathecal administration, efficacy
p. 412-417 of the original issue
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Address for correspondence:
212026, Republic of Belarus,
Mogilev, B.Biruli str, 12,
Mogilev Regional Hospital,
Anesthesiology and Intensive Care Unit,
Piacherski Valery G.
Information about the authors:
Piacherski Valery G., PhD, Head of Anesthesiology and Intensive Care Unit, Mogilev Regional Hospital, Trainee Teacher of the Branch of the Department of Anesthesiology and Reanimatology with a Course of the Advanced Training and Retraining Faculty and Surgery with a Course of the Advanced Training and Retraining Faculty, Vitebsk State Medical University, Mogilev, Republic of Belarus.
Muzyka Lidziya V., Anesthesiologist-resuscitator of Anesthesiology and Intensive Care Unit, Mogilev Regional Hospital, Mogilev, Republic of Belarus.
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