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Year 2020 Vol. 28 No 1

SCIENTIFIC PUBLICATIONS
GENERAL & SPECIAL SURGE

S.G. ALI-ZADE, SH.K. NAZAROV, P.K. KHOLMATOV

TIM-3 LEVEL IN BLOOD SERUM IN ACUTE PANCREATITIS IN EARLY STAGE

Tajik State Medical University, Dushanbe,
The Republic of Tajikistan

Objective. To study the expression of the serum TIM-3 (sTIM-3) in patients with acute pancreatitis in the early stage.
Methods. 44 patients with acute pancreatitis were examined who were admitted to the surgical departments of the city clinical emergency hospital in Dushanbe in the period from 2017 to 2019. The 1st group included 16 patients with mild acute pancreatitis; the 2nd group included 28 patients with moderate to severe acute pancreatitis. The control group (CG) consisted of 20 healthy volunteers. In the studied patients, the disease severity was assessed according to the APACHE II scale, the level of sTIM-3 in the blood serum and the levels of cytokines IL-6, IL-10 and TNF-α were established with the determination of the correlation between them.
Results. The levels of IL-6 and TNF-α were significantly higher in the 2nd group of patients with severe acute pancreatitis than in the 1st group of patients and the control group. The level of IL-10 in the 2nd group was significantly lower than in the 1st group. The sTIM-3 indices in the 1st and 2nd groups of patients were significantly higher than in the control group. In turn, in patients of the 2nd group, the level of sTIM-3 was significantly higher than in the 1st group. A direct correlation between the level of sTIM-3 and the levels of IL-6 and TNF-α was revealed, whereas between sTIM-3 and the level of IL-10 no significant relationship was found. A direct correlation between the sTIM-3 level and the APACHE II score was determined (r=0.545, p<0.001).
Conclusions. It has been established that the level of sTIM-3 varies depending on the severity of acute pancreatitis, and inhibition of sTIM-3 activation can have a therapeutic effect on the excessive inflammatory response. Measurement of serum sTIM-3 may be an early marker for predicting acute pancreatitis.

Keywords: acute pancreatitis, pancreonecrosis, diagnosis, treatment, immunoglobulins
p. 24-29 of the original issue
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Address for correspondence:
734003, Republic of Tajikistan,
Dushanbe, Rudaki Ave.,139,
Tajik State Medical University,
Surgical Diseases Department №1.
Tel. +992 928 21-77-55,
e-mail: suhrob_a@mail.ru,
Sukhrob G. Ali-Zade
Information about the authors:
Ali-Zade Sukhrob G., PhD, Assistant of the Surgical Diseases Department No1, Tajik State Medical University, Dushanbe, Republic of Tajikistan.
https://orcid.org/0000-0002-2456-7509
Nazarov Shohin K., MD, Professor, Head of the Surgical Diseases Department No1, Tajik State Medical University, Dushanbe, Republic of Tajikistan.
https://orcid.org/0000-0003-2099-2353
Kholmatov Pulat K., PhD, Associate Professor of the Surgical Diseases Department No1, Tajik State Medical University, Dushanbe, Republic of Tajikistan.
https://orcid.org/0000-0001-8025-0832
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