Novosti
Khirurgii

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Year 2018 Vol. 26 No 3

REVIEWS

V.E. MILYUKOV 1, A.V. BOGDANOV 2

THE ROLE OF ADRENAL GLANDS IN THE MECHANISMS OF STRESS EFFECTS ON PATHOGENESIS
OF COMPLICATIONS IN ACUTE SMALL BOWEL OBSTRUCTION (REVIEW)

I.M. Sechenov First Moscow State Medical University (Sechenov University)1,
Medical-Sanitary Unit of the Ministry of Internal Affairs of the Russian Federation in Moscow2, Moscow,
The Russian Federation

The aim of this review is a detailed description of the alleged mechanisms of involving the adrenal glands, as a key element of the system of nonspecific protection of an organism and adaptation to stress, in the pathogenesis of clinical manifestations of acute small bowel obstruction and developing complications, including peritonitis, sepsis and multiple organ failure.
In the discussion of the pathogenesis of clinical manifestations of acute small bowel obstruction and its complications, leading to the disappointing results of treatment of patients on a large sample of contemporary scientific publications, it is noted that many researchers see a close connection between the influence of various stress effects on humans and the functioning of internal organs and systems. It is demonstrated that in the literature there is growing evidence of the negative effects of stress and related affective disorders on the course of inflammatory bowel diseases and gastrointestinal tract, which is one of the targets of stress, and hormones of the hypothalamic-pituitary-adrenal system, especially the adrenal glands take an active part in the mediation of these reactions.
The conducted analysis of the current literature demonstrates a large number of unsolved issues in this direction, that proves the need for a comprehensive experimental and morphological studies to clarify and detail all pathogenetic links of dependent morpho-functional transformations in the dynamics of development of acute small bowel obstruction which may lead to adrenal insufficiency and disruption of adaptation mechanisms that maintain the stability of homeostasis.

Keywords: acute small bowel obstruction, peritonitis, sepsis, stress, adrenal insufficiency
p. 366-375 of the original issue
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Address for correspondence:
103904, The Russian Federation,
Moscow, Mokhovaya Str., 11, b.10,
I.M. Sechenov First Moscow
State Medical University,
Department of Human Anatomy,
Tel. mobile: +7-916-156-41-27,
e-mail: Milyucov@mail.ru,
Vladimir E. Milyukov
Information about the authors:
Milyukov Vladimir E., MD, Professor of the Department of Human Anatomy of the Medical Faculty, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
http://orcid.org/0000-0002-8552-6727
Bogdanov Alexandr V., Surgeon, Head of the Admission Unit, Medical-Sanitary Unit of the Ministry of Internal Affairs of the Russian Federation in Moscow, Moscow, Russian Federation
http://orcid.org/0000-0002-3222-9462
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