Year 2017 Vol. 25 No 6

ONCOLOGY

Y.B. RADZISHEVSKA 1,2, L.Y. VASILEV 1, V.G. KNIGAVKO 2, N.I. LYKHOVITSKAYA 1

RELATIONSHIPS OF NOSOLOGICAL FORM OF THE PRIMARY AND SECOND NEOPLASMS IN ONCOLOGICAL PATIENTS

SE Institute of Medical Radiology named after S.P. Grigoriev
of the National Academy of Medical Sciences of Ukraine 1,
Kharkov National Medical University 2, Kharkov,
Ukraine

Objective. To investigate the relationship between nosological forms of the primary and second neoplasms in patients who have undergone special treatment for cancer, and who have developed second neoplasms three and more years after the end of treatment.
Methods. The study has compared the nosological structure of second neoplasms that developed in 203 patients undergoing treatment for oncological pathology with the official data on the specific weight of 10 major nosological forms of malignant neoplasms in Ukraine. The statistical significance of the obtained results has been estimated using confidence intervals normalized taking into account the specificity of the patients of the clinic where the study was conducted.
Results. In accordance with the specific weight of the nosological forms of the primary neoplasms, conditioned first by the specialization of the clinic, the study groups were divided into 5 nosological subgroups: patients with breast, thyroid, uterine, cervical, ovarian, and subgroup with other forms of cancer. For each of the subgroups, the nosological structure of the second neoplasms was investigated and compared with the overall structure of malignant neoplasms according to the official statistics. It is shown that the frequencies of five allocated nosological forms calculated for the clinic correspond fairly well to the population mean, while for two most representative nosological forms the correspondence is within the expected stochastic variability. Thus, it has been demonstrated that there are no statistically significant differences between the percentage composition of 10 major nosological forms of cancer in Ukraine and the structure of nosological forms of second neoplasms in the study group of patients.
Conclusions. The nosological form of second neoplasms is not a consequence of the primary cancer, but reproduces the overall nosological structure of the incidence of malignant neoplasms.

Keywords: primary neoplasms, second neoplasms, incidence structure of malignant neoplasms, etiology of second cancers
p. 613-620 of the original issue
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Address for correspondence:
61024, Ukraine,
Kharkov, Pushkinskaya str., 82,
SE Institute of Medical Radiology
named after S.P. Grigoriev,
Medical Informatics Group,
tel. office: +380 (67) 799-36-63,
e-mail: radzishevska@ukr.net,
Evgeniya B. Radzishevska
Information about the authors:
Radzishevska E.B., PhD, Head of the Medical Informatics Group of SE Institute of Medical Radiology named after S.P. Grigoriev of the National Academy of Medical Sciences of Ukraine, Associate Professor of the Department of Medical and Biological Physics and Medical Informatics of Kharkov National Medical University.
Vasilev L.Y., PhD, Head Physician of SE Institute of Medical Radiology named after S.P. Grigoriev of the National Academy of Medical Sciences of Ukraine.
Knigavko V.G., Doctor of Biological Sciences, Professor, Head of the Department of Medical and Biological Physics and Medical Informatics of Kharkov National Medical University.
Lykhovitskaya N.I., PhD, Researcher of the Nuclear Medicine Department of SE Institute of Medical Radiology named after S.P. Grigoriev of the National Academy of Medical Sciences of Ukraine.
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