Novosti
Khirurgii

 This journal is
indexed in Scopus
journal cover
android icon Android Applicaion
Íàø ñàéò èñïîëüçóåò ôàéëû cookie äëÿ ñáîðà ñòàòèñòèêè. Íàæàâ «Ïðèíÿòü», âû äàåòå ñîãëàñèå íà îáðàáîòêó ôàéëîâ cookie â ñîîòâåòñòâèè ñ Ïîëèòèêîé îáðàáîòêè ôàéëîâ cookie .
Ïðèíÿòü

Year 2017 Vol. 25 No 6

REVIEWS

V.N. ZASIMOVICH, N.N. IOSKEVICH

REPERFUSION (REOXYGENATION) INJURY AS A PROBLEM OF THE ARTERY RECONSTRUCTIVE SURGERY IN ATHEROSCLEROTIC GENESIS CHRONIC ISCHEMIA OF THE LOWER LIMBS

ME “Brest Regional Hospital”1, Brest
EE “Grodno State Medical University”2, Grodno
The Republic of Belarus

Objective. To perform the analysis of literature sources dedicated to the problem of reperfusion (reoxygenation) injury after revascularization of the lower limbs.
Methods. The native and foreign literature data have been analyzed concerning the investigation stages of the problem, pathogenesis, clinical manifestations of reperfusion (reoxygenation) injury and methods of its prediction, prevention and correction for recent 20 years.
Results. The steady increase in atherosclerosis incidence, quantitative rise of lower limbs revascularization determines an increase in the frequency of reperfusion injury, significantly reducing the effectiveness of surgical interventions, impeding the restoration of function and, often, and preservation of the limb. Post-reperfusion injuries of the organs and systems remote from the lower limbs result in an evident life quality decline and lethality increase. The generalization of data on the studies of various links in the pathogenesis of ischemia-reperfusion and the methods of its correction indicate their fragmentation. The relationship between the severity of reperfusion injuries and the initial degree of the limb ischemia has not been adequately investigated.
Conclusions. Necessity in improvement of the surgical treatment results of chronic lower limb ischemia requires systemic researches on the correlation of disturbances of prooxidant-antioxidant balance, oxygen transport function, electrolyte and energy balance, depending on the degree of ischemia. This will allow developing the criteria for the severity of reperfusion (reoxygenation) injury, algorithms of its prediction, diagnosis, and correction. There is an urgent need to create a practically meaningful classification of ischemia-reperfusion, to determine the laboratory criteria for the degree of its severity, and to develop schemes for its medicinal prevention and treatment.

Keywords: reperfusion injury, revascularization, peripheral artery disease, atherosclerosis, prooxidant-antioxidant balance, oxygen transport function
p. 632-642 of the original issue
References
  1. Kalmykov EL, Skrypnik DA, Vinogradov RA, Gaibov AD. 30-i kongress evropeiskogo obshchestva sosudistykh khirurgov (Kopengagen, Daniia, 28-30 sentiabria 2016g.) [The 30th Congress of the European Society of Vascular Surgeons (Copenhagen, Denmark, September 28-30, 2016)]. Angiologiia i Sosud khirurgiia. 2017;(1):143-47.
  2. Moler III ER, Dzhaff MR, red. Zabolevaniia perifericheskikh arterii [Diseases of peripheral arteries]. Per. s angl. Pisarev MV, red. Moscow, RF: GEOTAR-Media; 2010. 224 p.
  3. Ianushko VA, Ioskevich NN, Lozhko PM, Turliuk DV, Ianushko AV. Khirurgiia aorty i ee vetvei [Surgery of the aorta and its branches]: atlas i ruk. Moscow, RF: Med lit; 2013. 224 p.
  4. Enge I, Edenberg J, Stuland T. Treatment with percutaneous transluminal angioplasty of the popliteal and crural arteries. Tidsskr Nor Laegeforen. 2004 Jan 22;124(2):173-75. [Norwegian]
  5. Wright LB, Matchett WJ, Cruz CP, James CA, Culp WC, Edidt JF. Popliteal artery disease: diagnosis and treatment. Radiographic. 2004 Mar-Apr;24(2):467-79.
  6. Belov IuV, Stepanenko AB. Povtornye rekonstruktivnye operatsii na aorte i magistral’nykh arteriiakh [Repeated reconstructive surgery on the aorta and main arteries]. Moscow, RF: MIA; 2009. 176 p.
  7. Koreiba KA, Kliushkin IV, Maksimov AV, Fatykhov RI, Nasrullaev MN. Reperfuzionnyi sindrom pri sosudistoi rekonstruktsii u bol’nykh s sindromom diabeticheskoi stopy [Reperfusion syndrome in vascular reconstruction in patients with diabetic foot syndrome]. Vestn Sovrem Klin Meditsiny. 2013;6(5):67-70.
  8. Kalinin RE, Pshennikov AS, Suchkov IA. Reperfuzionnoe povrezhdenie tkanei v khirurgii arterii nizhnikh konechnostei [Reperfusion injury of tissues in surgery of arteries of lower extremities]. Novosti Khirurgii. 2015;23(3):348-52.doi: 10.18484/2305-0047.2015.3.348.
  9. Natsional’nye rekomendatsii po vedeniiu patsientov s zabolevaniiami arterii nizhnikh konechnostei [National guidelines for management of patients with lower limb arteries]. Moscow, RF: Meditsina; 2013. 74 p.
  10. Blaisdell FW. The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review. Cardiovasc Surg. 2002 Des;10(6):620-30.
  11. Dick F, Li J, Giraud MN, Kalka C, Schmidli J, Tevaearai H. Basic control of reperfusion effectively protects against reperfusion injury in a realistic rodent model of acute limb ischemia. Ñirculation. 2008 Nov 4;118(19):1920-28.
  12. Kuznetsov MR, Koshkin VM, Komov KV. Sovremennye aspekty diagnostiki, profilaktiki i lecheniia reperfuzionnogo sindroma [Modern aspects of diagnosis, prevention and treatment of reperfusion syndrome]. Angiologiia i Sosud Khirurgiia. 2006;12(1):133-43.
  13. Baines CP. How and when do myocytes die during ischemia and reperfusion: the late phase. J Cardiovasc Pharmacol Ther. 2011 Sep-Dec;16(3-4):239-43.
  14. Coats P, Hillier C. Differential responses in human subcutaneous and skeletal muscle vascular beds to critical limb ischemia. Eur J Vasc Endovasc Surg. 2000 Apr;19(4):387-95.
  15. Edrees WK, Lau LL, Young IS, Smye MG, Gardiner KR, Lee B, et al. The effect of lower limbs ischemia-reperfusion on intestinal permeability and the systemic inflammatory response. Eur J Vasc Surg. 2003 Apr;25(Is 4):330-35.
  16. Gavrilenko AV, Shabaltas ED. Sostoianie mikrotsirkuliatsii pri reperfuzionnom sindrome posle rekonstruktivnykh operatsii na sosudakh nizhnikh konechnostei [The state of microcirculation in reperfusion syndrome after reconstructive operations on the vessels of the lower limbs]. Khirurgiia Zhurn im NI Pirogova. 2003;(2):62-65.
  17. Shval’b PG, Kalinin RE. Antioksidantnaia zashchita i funktsional’noe sostoianie endoteliia u bol’nykh obliteriruiushchim aterosklerozom nizhnikh konechnostei do i posle operativnogo lecheniia [Antioxidant protection and functional state of the endothelium in patients with obliterating atherosclerosis of the lower limbs before and after surgical treatment]. Khirurgiia Zhurn im NI Pirogova. 2009;(1):53-55.
  18. Marshalov DV, Petrenko AP, Glushach IA. Reperfuzionnyi sindrom: poniatie, opredelenie, klassifikatsiia [Reperfusion syndrome: concept, definition, classification]. Patologiia Krovoobrashcheniia i Kardiokhirurgiia. 2008;(3):67-72.
  19. Ioskevich NN. Khirurgiia khronicheskoi ishemii nizhnikh konechnostei ateroskleroticheskogo geneza [Surgery of chronic ischemia of lower extremities of atherosclerotic origin]. Grodno, RB: GrGMU; 2007. 315 p.
  20. Bilenko MV. Ishemicheskie i reperfuzionnye povrezhdeniia organov (molekuliarnye mekhanizmy, puti preduprezhdeniia i lecheniia) [Ischemic and reperfusion injury of organs (molecular mechanisms, ways of prevention and treatment]. Moscow, RF: Meditsina; 1989. 368 p.
  21. Makeeva AV, Popova TN, Sukhoveeva OV, Panchenko LF. Vliianie guanidinovykh proizvodnykh na aktivnost’ superoksiddismutazy i katalazy pri postishemicheskoi reperfuzii golovnogo mozga u krys [The effect of guanidine derivatives on the activity of superoxide dismutase and catalase in postischemic brain reperfusion in rats]. Neirokhimiia. 2010;(3):245-50.
  22. Barsukov AE, Makhnov NA. Disfunktsiia endoteliia: printsipy diagnostiki i klinicheskaia znachimost’ pri obliteriruiushchem ateroskleroze perifericheskikh arterii [Endothelial dysfunction: the principles of diagnosis and clinical significance for obliterating atherosclerosis of peripheral arteries]. Vestn Khirurgii im II Grekova. 2005;164(1):102-104.
  23. Kashibadze KN, Napashidze IM. Oksidantno-antioksidantnye protsessy v tkaniakh pri ishemicheskom i reperfuzionnom povrezhdeniiakh tonkogo kishechnika [Oxidant-antioxidant processes in tissues in ischemic and reperfusion injuries of the small intestine]. Patol Fiziologiia i Eksperim Terapiia. 2009;(2):19-21.
  24. Manukhina EB, Terekhina OL, Belkina LM, Abramochkin DV, Budanova OP, Mashina SI, i dr. Vazoprotektornyi effekt adaptatsii pri ishemicheskom i reperfuzionnom povrezhdenii serdtsa [Vasoprotective adaptative effect in ischemic and reperfusion injury of the heart]. Patol Fiziologiia i Eksperim Terapiia. 2013;(4):26-31.
  25. Kalinin RE, Suchkov IA, Pshennikov AS. Endotelial’naia disfunktsiia i sposoby ee korrektsii pri obliteriruiushchem ateroskleroze [Endothelial dysfunction and ways of its correction with obliterating atherosclerosis]. Moscow, RF: GEOTAR-Media; 2014. 152 p.
  26. Sergienko VI, Petrosian EA, Onopriev VI, Laipanov KhIKhM. Morfologicheskie izmeneniia legkikh pri modelirovanii i lechenii ishemicheskikh i reperfuzionnykh povrezhdenii konechnosti [Morphological changes in the lungs in the modeling and treatment of ischemic and reperfusion injury of the limb]. Obshch Reanimatologiia. 2006;2(5-6):129-32.
  27. Shcherbak NS, Galagudza MM, Iutkina GIu, Barantsevich ER, Tomson VV, Shliakhto EV. Morfofunktsional’nye izmeneniia piramidnykh neironov razlichnykh polei gippokampa pri ishemicheskom postkonditsionirovanii [Morphofunctional changes of pyramidal neurons of various fields of the hippocampus in ischemic post-conditioning]. Morfologiia. 2013;(3):7-13.
  28. Ioannou A, Dalle Lucca J, Tsokos GC. Immunopatogenesis of ischemia/reperfusion-associated tissue damage. Clin Immunol. 2011 Okt;141(1):3-14.
  29. Ioskevich NN, Zinchuk VV. Prooxidant-antioxidant balance in blood during the surgical treatment of obliterating arterial atherosclerosis in the lower extremities. Rocz Acad Med Bialst. 2004;49:222-26.
  30. Gladwin MT, Kato GJ, Weiner D, Onyekwere OC, Dampier C, Hsu L, et al. Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial. JAMA. 2011;305(9):893-902.
  31. Rodrigues SF, Granger DN. Role of blood cells in ischemia-reperfusion-induced endothelial barrier failure. Cardiovasc Res. 2010 Jul 15;87(2):291-99.
  32. Gourdin MJ, Bree B, De Kock M. The impact of ischemia-reperfusion on the blood vessel. Eur J Anaesthesiol. 2009 Jul;26(7):537-547.
  33. Proebstl D, Voisin MB, Woodfin A, Whiteford J, D Añquisto F, Jones GE, et al. Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med. 2012 Jun 4;209(6):1219-34.
  34. Depre C, Park JY, Shen YT, Zhao X, Qiu H, Yan L, et al. Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H752-62.
  35. Savel’ev VS, Kirienko AI, red. Klinicheskaia khirurgiia [Clinical Surgery ]: nats ruk: v 3 t. Moscow, RF: GEOTAR-Media; 2010;III. 1008 p.
  36. Suchkov IA, Pshennikov AS, Gerasimov AA, Agapov AB, Kamaev AA. Profilaktika restenozov v rekonstruktivnoi khirurgii magistral’nykh arterii [Prevention of restenosis in reconstructive surgery of the main arteries]. Nauka Molodykh - Eruditio Juvenium. 2013;(2):12-19.
  37. Suchkov IA, Kalini RE. Endoteliotropnaia terapiia kak sposob profilaktiki restenoza zony rekonstruktsii i korrektsii disfunktsii endoteliia u patsientov s obliteriruiushchim aterosklerozom arterii nizhnikh konechnostei [Endotheliotropic therapy as a way to prevent restenosis of the zone of reconstruction and correction of endothelial dysfunction in patients with obliterating atherosclerosis of the arteries of the lower extremities]. Kardiologiia i Serdech-Sosud Khirurgiia. 2013;6(5):54-57.
  38. Rautou PE, Vion AC, Amabile N, Chironi G, Simon A, Tedgui A, et al. Microparticles, vascular function and atherothrombosis. Circ Res. 2011 Aug 19;109(5):593-606.
  39. Iakusheva EN, Chernykh IV, Shul’kin AV, Gatsanoga MV. Ishemiia i ishemiia-reperfuziia kak moduliator funktsionirovaniia belka-transportera glikoproteina-R [Ischemia and ischemia-reperfusion as a modulator of the glycoprotein-P protein transporter]. Farmatsiia i Farmakologiia.2015;(5s):124-25
  40. Khiabani HZ, Anvar MD, Kroese AJ, Stranden E. Transcapillary forces and the development of oedema in the lower limb of patients with chronic critical ischemia (CLI). Eur J Vasc Endovasc Surg. 2000;19(6):598-604.
  41. Kozlov IA, Romanov AA, Dzybinskaia EV, Balandiuk AE. Ingaliatsionnyi oksid azota dlia profilaktiki narusheniia arterial’noi oksigenatsii pri revaskuliarizatsii miokarda s iskusstvennym krovoobrashcheniem [Inhalation nitric oxide for the prevention of arterial oxygenation disorders in myocardial revascularization with artificial circulation]. Obshch Reanimatologiia. 2011;7(1):31-35.
  42. Savel’ev VS, Koshkin VM, Kunizhev AS. Kriticheskaia ishemiia, kak sledstvie neadekvatnogo lecheniia bol’nykh khronicheskimi obliteriruiushchimi zabolevaniiami arterii nizhnikh konechnostei na ambulatornom etape [Critical ischemia, as a result of inadequate treatment of patients with chronic obliterating diseases of the arteries of the lower extremities at the outpatient stage]. Angiologiia i Sosudistaia Khirurgiia. 2004;10(1):7-11.
  43. Harkin DW, Barros DSaAA, McCallion K, Hoper M, Halliday MI, Campbell FC. Bactericidal/permeability-increasing protein attenuates systemic inflammation and acute lung injury in porcine lower limb ischemia-reperfusion injury. Ann Surg. 2001 Aug; 234(2):233-44.
  44. Inchina VI, Smirnov LD, Romanov MD, Kokoreva EV, Morozov MIu. Angioprotektivnaia aktivnost’ meksikora pri obliteriruiushchem ateroskleroze arterii nizhnikh konechnostei [Angioprotective activity of mexicore with obliterating atherosclerosis of arteries of lower extremities]. Angiologiia i Sosud. Khirurgiia. 2007;13(3):17-20.
Address for correspondence:
224027, Republic of Belarus,
Brest, Meditsinskaya str., 7,
ME "Brest Regional Hospital",
Vascular Surgery Unit,
Tel.office: +375 162 27-23-64,
E-mail: zasimovich.v@gmail.com,
Vladimir N. Zasimovich
Information about the authors:
Zasimovich V.N., Head of the Vascular Surgery Unit of ME “Brest Regional Hospital”.
Ioskevich N.N., MD, Professor of the Department of Surgical Diseases ¹1 of EE “Grodno State Medical University”.
Contacts | ©Vitebsk State Medical University, 2007-2023