Novosti
Khirurgii
This journal is
indexed in Scopus









Year 2017 Vol. 25 No 4

GENERAL & SPECIAL SURGERY

DOI: https://dx.doi.org/10.18484/2305-0047.2017.4.359   |  

K.M. KURBONOV, K.R. NAZIRBOEV

ENDOTOXICOSIS AND INDICATORS OF CYTOKINE LEVEL IN PATIENTS WITH NON-TUMOR OBSTRUCTIVE JAUNDICE

Avicenna Tajik State Medical University, Dushanbe,
The Republic of Tajikistan

Objectives. To study some indices of endtoxicosis and the level of cytokines in blood serum and bile in patients with non-tumor obstructive jaundice.
Methods. The studies are based on a comparative analysis of indicators of endotoxemia and cytokine profile in the blood serum and duct bile in 38 operated patients. Patients on the basis of the severity of obstructive jaundice (OJ) were divided into 3 groups according to the classification of E.I. Galperin et al. There were 12 patients with OJ in mild form (31,6%), with moderate severity 14 (36,8%) and with severe form of OJ 12 (31,6%). To diagnose the severity of OJ, laboratory studies of endotoxemia indices and cytokine concentration in the blood serum and duct bile were performed, and morphological data of the liver biopsy samples were also studied.
Results. Analysis of the study results has shown the concentration of the proinflammatory cytokine IL-6 in OJ of medium severity is 50,4% higher than normal, and at a severe degree in the blood serum it turns out to be the highest in case of OJ complicated by purulent cholangitis by 2,4 times. The concentration of proinflammatory cytokine IL-6 in the bile has been found to be elevated in patients with OJ (a moderate severity) and OJ (severe form).
During the study, the concentration of proinflammatory cytokine IL-4 in the blood serum in OJ of a mild degree was 27% higher than normal, and in patients with OJ of a moderate severity 67,3% higher. However, the concentration of IL-4 in the bile appeared to be elevated in case of the initial forms of the disease compared with patients with OJ of a moderate severity against the destructive cholecystitis.
Conclusion. The results of a comprehensive study of patients with OJ have revealed significant changes in indices of the cytokine status and endotoxemia in the blood serum and bile as well as morphofunctional changes in the liver.

Keywords: cholelithiasis, choledocholithiasis, obstructive jaundice, endotoxemia, cytokines, bile, liver
p. 359-364 of the original issue
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Address for correspondence:
734003, Republic of
Tajikistan, Dushanbe,
Rudaki Ave., 139,
The Tajik State
Medical University
named after Abuali ibni Sino,
Department of Surgical
Diseases N 1,
Tel .: +992 93 405-44-04,
E-mail: dr.hero85@mail.ru,
Kahramon R. Nazirboev
Information about the authors:
Kurbonov K.M. Academician of the Academy of medical sciences of the Republic of Tajikistan , Honored Worker of Science and Technology of RT, MD, Professor, Head of department of surgical diseases N1, Avicenna Tajik State Medical University.
Nazirboev K.R. PhD, Assistant of department of surgical diseases N1, Avicenna Tajik State Medical University.
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