This journal is
indexed in Scopus
Year 2017 Vol. 25 No 4
A.V. ZHURA1, S.I. TRATSYAK 1, V.J. KHRYSHCHANOVICH2, Z.A. MAKAREVICH1
EXPERIMENTAL MODEL OF PERITONEAL ADHESION
EE “Belarusian State Medical University” 1,
SEE “Belarusian Medical Academy of Post-Graduate Education” 2,
The Republic of Belarus
Objectives. To develop an experimental model of peritoneal adhesions that is close to clinical practice, simple to implement, with a high incidenceof adhesion formation and a small number of complications.
Methods. Several experimental models were chosen with singling out three groups: injury of cecum serosa (group 1, n=6), ileum enterotomy with subsequent suturing of the defect (group 2, n=8), and model made by the authors, including the excision of the peritoneum on the contralateral sides of the abdominal wall (group 3, n=22). Third group was divided into two subgroups – with and without bacterial contamination of the peritoneal cavity.
Results. There were no abdominal adhesions in animals of the first group. In future this model was abandoned. Opening of the intestinal lumen and its suturing (group 2) induced adhesions in all animals; however, it was variably localized in the peritoneal cavity. Intestinal insufficiency of sutures was observed in two cases. In addition, in second group operation time was the longest (17 min) in comparison with 7 minutes in the first group and 5 minutes in the third group. Excision of the parietal peritoneum with abdominal contamination (subgroup 3a) was characterized by the largest number of complications with the development of intra-abdominal abscesses and infiltrates, high lethality, and overproduction of adhesion process going beyond the limits of modeling. Excision of the parietal peritoneum without contamination (subgroup 3b) induced adhesion formation in 75 % of cases with the localization of adhesions in the regions of modeling only, without morbidity and mortality.
Conclusion. A suggested experimental model of peritoneal adhesions leads to adhesion formation in large number of cases with minimal number of complication, appears to be simple, and is thought to be recommended for research of the adhesion process.
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220007, Republic of Belarus,
Minsk, Dzerzhinsky Ave., 83,
Belarusian State Medical University,
department of surgical diseases N2,
Tel.: + 375 (29) 668-50-21,
Alexander V. Zhura
Zhura A.V. PhD, Assistant of department of surgical diseases N2, EE “Belarusian State Medical University”.
Tratsyak S.I. MD, Professor, Corresponding member of NAS of Belarus, Head of department of surgical diseases N2, EE “Belarusian State Medical University”.
Khryshchanovich V.J. MD, Ass. Professor, Head of department surgery, SEE “Belarusian Medical Academy of Post-graduate Education”.
Makarevich Z.A. Vivarium manager of EE “Belarusian State Medical University”.