Year 2016 Vol. 24 No 2

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

A.O. KOVALCHUK

MORPHOMETRIC INDICATORS OF EXPERIMENTAL BURNS IN ANIMAL MODELS DURING EARLY SURGICAL TREATMENT WITH THE USE OF HYDROGEL DRESSINGS AND POLYURETHANE ADSORBENTS

Ternopol State Medical University Named after I.Y.Gorbachevsky,
Ukraine

Objectives. To carry out the morphometric analysis of the skin layers affected by thermal factor in early necrectomy performance with subsequent wound closure by means of hydrogel dressings and spongy polyurethane adsorbents.
Methods. The study was conductred on mature white outbred rats (n=192), weighing 250-300 g. Due to the European Convention for the Protection of Vertebrate Animals Used for Experimental and other Scientific Purposes, the damage conducted under general ether anaesthesia according to Regas F.C., Ehrlich H.P. (1992). Experimental injury procedure included contact third and fourth degree burns at skin hair free back. The burn was applied by copper plates heated in boiling water to 97-100C under ether anesthesia within 20 sec. The size of the lesion was 10-15% of the body.
Results. Hydrogel dressings with an additional absorbent layer had been shown to be effective in positive dynamic regenerative process.
At all stages of the experimental study, absolute fixation of the gauze hydrogel covering on the wounds with no disruption and lysis was observed. The perforated structure of primary dressings and high sorbing ability of polyurethane sponge provided active exudate drain, and made favourable conditions for local therapeutic effect of the regenerative substrate, which is manifested by adjacent tissue edema reduction, normal blood circulation and complete restoration of the affected dermis structure. Thus, a burn wound closure by combination of hydrogel dressing and polyurethane sponge promoted active granulation tissue formation, provided wound healing and anti-inflammatory effects.
Conclusion. The performed research has proved the efficacy of early performance of necrectomy, helped to promote wound healing by means of hydrogel dressings and polyurethane adsorbents.

Keywords: burns, morphometry, necrectomy, hydrogel dressings, polyurethane sponge adsorbents, granulation tissue, anti-inflammatory
p. 109-119 of the original issue
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Address for correspondence:
46000, Ukraine,
ernopol, ul. Shpitalnaya, d. 2,
Ternopolskiy gosudarstvennyiy meditsinskiy universitet
imeni I.Y. Gorbachevskogo,
kafedra travmatologii i ortopedii s voenno-polevoy khirurgiey,
tel. office: 38 096 7517885,
e-mail: kovalchuk.derm@yandex.ru,
Kovalchuk Andrey Olegovich
Information about the authors:
Kovalchuk A.O. An associate professor of the traumatology and orthopedic chair with military field surgery of Ternopol State Medical University named after I.Y.Gorbachevsky of the Ministry of Health of Ukraine.
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