Novosti
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This journal is indexed in Scopus |
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Year 2014 Vol. 22 No 3
NEW METHODS
V.V. ANICHKIN, E.A. POVELITZA, V.V. MARTINUCK
A METHOD OF ATYPICAL LIVER RESECTION WITH ANTIPARASITIC TREATMENT OF HEPATIC TISSUE WITH THE MIXTURE OF GLYCEROL AND 1-2% SOLUTION OF ALBENDAZOLE IN DIMEXIDUM IN PATIENTS SUFFERING FROM HEPATIC ECHINOCOCCOSIS
EE “Gomel State Medical University”,
The Republic of Belarus
Objectives. To work out a new method of the atypical liver resection with the antiparasitic treatment of liver tissue.
Methods. 6 patients suffering from the hepatic echinococcosis underwent the surgery from 2002 to 2013 yrs. are under the survey. All patients underwent a comprehensive examination including clinical, functional, laboratory and instrumental methods of diagnosis. In all cases the diagnosis was verified by morphological examination of surgical material. In surgical treatment of echinococcosis with a parasitic cyst the atypical liver resection was performed. In all cases the surgery was completed with the intraoperative antiparasitic treatment of the liver tissue by the mixture of glycerol and 1-2% solution of albendazole in dimexidum (ratio 2,3:1). Clearance efficacy of germinal cells was assessed by means of the washouts microscopically prior and after antiparasitic treatment. During the postoperative period all patients underwent the generic course of albendazole chemotherapy (the dosage 10-15 mg/kg, the maximum dosage – 800 mg/ per day). Each course lasted for 1 month, the number of courses were no less than 3 per each person.
Results. The stay of patients in hospital varied from 14 to 21 days. The patients receiving the combined treatment (surgical and chemotherapeutic) had good and satisfactory short- and long-term results; there were no relapses of the disease during the period from 3 to 6 years. Cases of surgical complications and deaths were not observed either.
Conclusions. The supplement of atypical liver resection by an intraoperative application of antiparasitic mixture of glycerol and 1-2% solution of albendazole in dimexidum combined with the course of albendazole chemotherapy according to the conventional scheme is a highly effective combination of surgical and chemotherapeutic methods of hepatic echinococcosis treatment, which provides the complete recovery of patients and allows preventing the development of surgical complications and relapse of the disease.
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246050, Respublika Belarus, g. Gomel, ul. Lange, d. 5, UO «Gomelskiy gosudarstvennyiy meditsinskiy universitet», kafedra khirurgicheskih bolezney ¹3 s kursom serdechno-sosudistoy khirurgii,
e-mail: vas.martinuck@yandex.ru,
Martinuck Vasiliy Vladimirovich
Anichkin V.V. MD, professor, professor of the surgical diseases chair ¹3 with the course of the cardiovascular surgery of EE “Gomel State Medical University”.
Povelitza E.A. PhD, an assistant of the surgical diseases chair ¹3 with the course of the cardiovascular surgery of EE “Gomel State Medical University”.
Martinuck V.V. An assistant of the surgical diseases chair ¹3 with the course of the cardiovascular surgery of EE “Gomel State Medical University”.
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