Year 2012 Vol. 20 No 3




EE Belarusian State Medical University, Minsk,
The Republic of Belarus

The primary aim of the cell encapsulation technology is the addressed delivery of the synthesized molecules to the target organ. The principle of the cell immunoisolation is the backgrounds of this method prior to transplantation donor cells are set in the semi-permeable membrane to protect them against their interaction with the hosts immune system. This membrane is selectively permeable to transport the nutrients and the products of the cellular secretion but relatively impermeable to larger molecules and cells of the hosts immune system. Besides the most immunoisolating devices have the internal matrix which contributes to the compact immobilization of cells inside the capsule. The proper choice of the synthetic materials and methods of their processing influences significantly the functioning efficacy of the semi-permeable membrane and matrix components. Up-to-date immunoisolating devices permit to reconstruct natural three-dimensional tissue environment thus maintaining functional activity and viability of the encapsulated cells. This review summarizes recent developments in the field of materials production used to make devices for cell encapsulation.

Keywords: cells, microencapsulation, macroencapsulation, alginate-polylysine capsules, transplantation
p. 100 116 of the original issue

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Address for correspondence:
220116, Respublika Belarus', g. Minsk, pr-t. Dzerzhinskogo, d. 83, UO Belorusskii gosudarstvennyi meditsinskii universitet, 2-ia kafedra khirurgicheskikh boleznei,
Khryshchanovich Vladimir Ianovich
Information about the authors:
Khryshchanovich V.Ya., Doctor of Medical Sciences, Associate Professor of the 2nd Department of Surgical Diseases of EE Belarusian State Medical University." Tretyak S.I., Doctor of Medical Sciences, Professor, Head of the 2nd Department of Surgical Diseases of EE Belarusian State Medical University."
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