Year 2011 Vol. 19 No 5




Objectives. To identify preoperative prognostic factors of biochemical recurrence (BCR) after surgical treatment of prostate cancer (PC) patients.
Methods. Data on 447 patients with clinically localized and locally-advanced PC who underwent open radical prostatectomy (RPE) in the period between 1997 and 2008 were included in the retrospective analysis. BCR-free survival was calculated by Kaplan-Meyer method. Mono- and multi variant of Cox proportional regression analyses were performed with preoperative variables.
Results. Patients from the low risk group had significantly higher 5-year BCR-free survival comparing to high risk group (71,35,2% and 35,84,7% respectively). Patients at high risk of BCR were those with prostate specific antigen (PSA) level of 10 ng/ml and more, Gleasons score in biopsy 7-10 or PSA 20 ng/ml and more regardless of Gleasons score.
Conclusions. The developed prognostic BCR model may optimize treatment tactics of PC patients in the Republic of Belarus.

Keywords: localized, locally-advanced prostate cancer, radical prostatectomy, biochemical recurrence
p. 96 101 of the original issue
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