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Year 2011 Vol. 19 No 5
E.SH. KHALILOV, S.A. KRASNY, A.I. ROLEVICH
PREOPERATIVE PROGNOSTIC FACTORS OF BIOCHEMICAL RECURRENCE AFTER RADICAL SURGICAL TREATMENT OF PATIENTS WITH PROSTATE CANCER
Objectives. To identify preoperative prognostic factors of biochemical recurrence (BCR) after surgical treatment of prostate cancer (PC) patients.
Methods. Data on 447 patients with clinically localized and locally-advanced PC who underwent open radical prostatectomy (RPE) in the period between 1997 and 2008 were included in the retrospective analysis. BCR-free survival was calculated by Kaplan-Meyer method. Mono- and multi variant of Cox proportional regression analyses were performed with preoperative variables.
Results. Patients from the low risk group had significantly higher 5-year BCR-free survival comparing to high risk group (71,3±5,2% and 35,8±4,7% respectively). Patients at high risk of BCR were those with prostate specific antigen (PSA) level of 10 ng/ml and more, Gleason‘s score in biopsy 7-10 or PSA 20 ng/ml and more regardless of Gleason‘s score.
Conclusions. The developed prognostic BCR model may optimize treatment tactics of PC patients in the Republic of Belarus.
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