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Year 2011 Vol. 19 No 1
GENERAL AND SPECIAL SURGERY
YAROVENKO G.V., VOLOVA L.T.,ZHUKOV B.N., KATORKIN S.E.
DYNAMICS OF CHANGES OF CYTOCINE PROFILE IN TREATMENT PROCESS OF PATIENTS WITH SECONDARY LYMPHEDEMA OF THE LOWER LIMBS
Objectives. To estimate the changes of cytokines of the blood serum in patients with secondary lymphedema of the lower limbs before or after conservative or operative treatment.
Methods. 81 patients with secondary lymphedema of the lower limbs have been examined: the 1st group (40 persons) with the 1–2 degrees of the disease and the 2nd group (41 persons) with the 3-4 degrees. Cytokines of the blood serum of patients of both groups have been tested: IL-1, IL-6, IL-10 and necrosis of tumor’s factor before and after conservative and surgical treatment.
Results. All patients’ changes of cytokines of the blood serum content have been revealed. More significant changes are defined in the patients with 3–4 degrees of secondary lymphedema of the lower limbs. After conservative treatment decline of all tested cytokines in both groups is observed, except IL-6. After surgical treatment wavy changes of parameters of cytokines with their further decline by 25th day have been fixed.
Conclusions. Quantitative changes of cytokines of the blood serum in patients with secondary lymphedema of the lower extremities were evidence of decline of immunity, especially with the 3–4 degree of disease which is necessary to take into account during pre-operation preparation to determine an optimal period of surgical correction at this group of patients.
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