Year 2009 Vol. 17 No 3

ONCOLOGY

S.V. JANUSKEVICS, J.V. EGLITIS, G.K. STOROZENKO, V.YU. JANUSKEVICS

BIOPSY OF AXILLARY SENTINEL LYMPH NODES AT ORGAN SAVING SURGERIES OF EARLY BREAST CANCER STAGES

Eighty nine women with early cancer (T1a,b,c) underwent the sentinel lymph node biopsy (SLNB) followed breast saving at Latvian Oncology center from 2002 till 2005. The sentinel lymph nodes (SLN) was mapped by radiological and contrast methods. For 33 SLN negative patients standard axillary lymph nodes dissection (ALND) was performed and in 32 (96,9%) cases lymph nodes were clear. The only one metastatic failure of 13 lymph nodes was found at second level of ALND false negative rate was 3,1%. In the group of 11 patients with positive SLN (12,4%) and followed ALND, nine of them were tumor-free. At the same time, metastasis was diagnosed twice (in 2 of 9 and 1 of 8 lymph nodes). ALND was avoided after negative SLNB for 45 patients. Main prognostic factors were considered at ALND planning time. Sensitivity, specificity and accuracy for SLNB as diagnostic test was statistically calculated and composed 91,6%, 100% and 96,8% accordingly.

Keywords: breast cancer, sentinel lymph node biopsy, axillary dissection
p. 121 - 126 of the original issue
References
  1. Observations on a Sentinel node in cancer of the paratid / E. A. Gould // Cancer. 1960. Vol. 13. P. 77-78.
  2. Cabanas, R. M. An approach for the treatment of penile carcinoma / R. M. Cabanas // Cancer. 1977. Vol. 39. P. 456-466.
  3. Functional lymphatic anatomy for sentinel node biopsy in breast cancer / P. J. Borgstein [et al.] // Ann. Surg. 2000. Vol. 232, N 1. P. 81-89.
  4. Giuliano, A. E. Sentinel lymphadenectomy in primary breast carcinoma: an alternative to routine axillary dissection / A. E. Giuliano // J. Surg. Oncol. 1996. Vol. 62, N 2. P. 75-79.
  5. The sentinel node in breast cancer: a multicenter validation study / D. Krag [et al.] // N. Engl. J. Med. 1998. Vol. 339. P. 941-946.
  6. Sentinel node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes / U. Veronesi [et al.] // The Lancet. 1997. Vol. 349. P. 1864-1867.
  7. Lymphatic mapping and sentinel lymph node biopsy in patients with breast cancer / C. E. Cox [et al.] // Ann. Rev. Med. 2000. Vol. 51. P. 525-542.
  8. Prediction of additional axillary metastasis of breast cancer following sentinel lymph node surgery / C. Changsri [et al.] // Breast. J. 2004.Vol. 10. P. 392-397.
  9. Kelley, M. C. Lymphatic mapping and sentinel lymphadenectomy for breast cancer / Am. J. Surg. 2004. Vol. 188. P. 49-61.
  10. Klimberg, S.V. A change in paradigm of breast cancer treatment Not technique for nodal staging / S. V. Klimberg // Ann. Surg. Oncol. 2003. Vol. 10, N 9. P. 1000-1001.
  11. Gurleyik, G. Accuracy of sentinel lymph node biopsy for the assessment of axillary status in patients with early (T1) breast carcinoma / G. Gurleyik [et al.] // JCPSP. 2005. Vol. 15, N 11. P. 697-700.
  12. Factors affecting metastases to non-sentinel lymph nodes in breast cancer / F. J. Fleming [et al.] // J. Clin. Pathol. 2004. Vol. 57. P. 73-76.
  13. Follow-up of cases with false-negative pathologic sentinel nodes in breast cancer / T. Nagashima [et al.] // Breast Cancer. 2004. Vol. 11. P. 175-179.
  14. Breast cancer patients treated without axillary surgery: clinical implication and biological analysis / M. Greco [et al.] // Ann. Surg. 2000. Vol. 232. P. 1-7.
  15. Hieken, T. J. The value of sentinel lymph node biopsy in elderly breast cancer patients / T. J. Hieken, S. Nettnin, J. M. Velasco // Am. J. Surg. 2004. Vol. 188. P. 440-442.
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