Year 2023 Vol. 31 No 3

SCIENTIFIC PUBLICATIONS

H.A. POPEL, I.A. MAISEYENKA, R.R. ZHMAILIK, YU.P. OSTROVSKY

COMPARATIVE ANALYSIS OF INFLAMMATORY RESPONSE IN ANIMAL ORGANISM AFTER ABDOMINAL AORTIC REPLACEMENT

Republican Scientific and Practical Center of Cardiology, Minsk,
Republic of Belarus

Objective. To study variations of inflammatory markers level after abdominal aortic replacement using biological (BG) and synthetic (SG) vascular gelatin-coated Dacron grafts in experimental animals.
Methods. The study was performed on female white pigs (n = 12). The animals were uniformly divided into two groups: group 1 implanted synthetic vascular modified gelatin-Dacron graft (6 animals); group 2 - implanted biological vascular graft using bovine xenopericardium (6 animals). The blood samples were taken before surgery and then on the 1st, 7th, 14th and 21st day postoperatively. To assess the systemic inflammatory response, the total number of white blood ulls, the absolute and relative numbers of granular and non-granular white blood ulls, the erythrocyte sedimentation rate and the concentration of C-reactive protein were determined.
Results. The total number of white blood ulls at all study points was not statistically significantly different in both groups: in the group of animals with a synthetic graft (p = 0.810) and in the group with a biological vascular graft (p = 0.170). On the 7th day after surgery, statistically significantly difference was reported in the concentration of C-reactive protein ( 1.78 (1.60-1.99) mg/l in the BP group and 1.24 (1.06-1.36) mg/l in the BG and SG group, p = 0.019) and the erythrocyte sedimentation rate ( 32.50 (31.00-36.25) mm/h and Me 19.50 (18.25-24.50) mm/h in the group of biological and synthetic grafts, respectively, p = 0.020). On the 14th and 21st day after surgery, there was no statistically significant difference in the study parameters.
Conclusion. No clinically significant difference in the intensity of the inflammatory response of experimental animals after abdominal aortic replacement with synthetic and biological vascular grafts was identified in the corresponding study.

Keywords: biological vascular graft, synthetic vascular graft, aorta, pig, inflammatory responce, xenopericardium
p. 181-189 of the original issue
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Address for correspondence:
220036, Republic of Belarus,
Minsk, R. Luxemburg Str. 110B,
Republican Scientific and Practical
Center Cardiology,
Vascular Surgery Research Laboratory,
tel.: +375 17 201-28-08,
e-mail: hpopel@mail.ru,
Popel Henadzi A.
Information about the authors:
Popel Henadzi A. PhD, Associate Professor, Head of Vascular Surgery Research Laboratory, Republican Scientific and Practical Center of Cardiology, Minsk, Republic of Belarus.
https://orcid.org/0000-0002-1140-0806
Maiseyenka Ivan A. Intern at Cardiac Surgery Department No.1, Researcher at Vascular Surgery Research Laboratory, Republican Scientific and Practical Center of Cardiology, Minsk, Republic of Belarus.
https://orcid.org/0000-0001-5403-7464
Zhmailik Ruslan R. Cardiac Surgeon at Cardiac Surgery Department No. 1, Researcher at Vascular Surgery Research Laboratory, Republican Scientific and Practical Center of Cardiology, Minsk, Republic of Belarus.
https://orcid.org/0000-0001-6342-3527
Ostrovsky Yury P. MD, Professor, Academician of NAS of Belarus and RAS, Vice-Director for Innovative Development and High Technologies, Republican Scientific and Practical Center of Cardiology, Minsk, Republic of Belarus.
https://orcid.org/0000-0001-6826-3200
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