Novosti
Khirurgii

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Year 2022 Vol. 30 No 4

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

R.E. KALININ, I. A. SUCHKOV, E. A. KLIMENTOVA, A.S. PSHENNIKOV

COMPREHENSIVE ASSESSMENT OF ENDOTHELIAL AND PLATELET-DERIVED GROWTH FACTORS ON RESTENOSIS DEVELOPMENT OF THE RECONSTRUCTION ZONE IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASIS

Ryazan State Medical University, Ryazan,
Russian Federation

Objective. Comprehensive assessment of the influence of vasculoendothelial growth factor A 165 and platelet-derived growth factor (PDGF) on the risk of development of reconstruction zone restenosis being one of the main postoperative complications in the remote postoperative period in patients with peripheral arterial disease.
Methods. The study included patients (n=47) with peripheral arterial disease (stage IIB-III) underwent the open interventions. In the period immediately prior the operation, in the first hours, and then on the 1st, 7th and 30th days after the operation, the amount of vasculoendothelial growth factor (VEGF A 165) and platelet-derived growth factor (PDGF) in the blood serum has been determined. In cases of the restenosis development of the intervention zone, a vascular wall sample with restenosis was taken intraoperatively for the subsequent examination of the studied biomarkers by enzyme immunoassay.
Results. In the first hours and on the first day after surgery, the amount of VEGF A165 in patients with restenosis was 2.2 fold and 1.8 fold, respectively, reduced in comparison with its values in patients without this complication (p<0.01). By the end of the first week, the PDGF values (p<0.01) were 1.4 fold higher in patients with restenosis of the intervention zone than in patients without restenosis. The difference between the compared groups in the indicated period of time in terms of VEGF A 165 was 85% (p<0.01). By the end of the first month, in patients with restenosis an increased level of the PDGF marker (p<0.01) retained against the background of decreased VEGF A 165 values (p=0.02) compared with patients without this complication.
Conclusion. VEGF A 165 values for the first hours is considered to be used as a prognostic marker for the restenosis development of the reconstruction zone after open lower extremity vascular interventions.

Keywords: re-endothelialization, atherosclerosis, VEGF A165, PDGF, vascular wall homogenate
p. 331-339 of the original issue
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Address for correspondence:
390026, Russian Federation,
Ryazan, st. Vysokovoltnaya, 9,
Ryazan State Medical University,
Department of Cardiovascular,
X-ray Endovascular Surgery
and Radiation Diagnostics,
Tel. +7-4912-97-18-03
E-mail: Suchkov_med@mail.ru
Suchkov Igor A.
Information about the authors:
Kalinin R.E., MD, Professor, Rector of the Ryazan State Medical University, Head of the Department of Cardiovascular, X-ray Endovascular Surgery and Radiation Diagnostics Ryazan State Medical University named after Academician I.P. Pavlov of the Ministry of Health of Russia.
https://orcid.org/0000-0002-0817-9573
Suchkov I.A., MD, Professor, Vice-Rector for Research and Innovative Development, Professor of the Department of Cardiovascular, X-ray Endovascular Surgery and Radiation Diagnostics, Ryazan State Medical University named after Academician I.P. Pavlov, Ministry of Health of Russia.
https://orcid.org/0000-0002-1292-5452
Klimentova E.A., Junior Researcher, Scientific and Educational Center, Ryazan State Medical University named after Academician I.P. Pavlov, Ministry of Health of Russia.
https://orcid.org/0000-0003-4855-9068.
Pshennikov A.S., MD, Associate Professor, Professor of the Department of Cardiovascular, X-ray Endovascular Surgery and Radiation Diagnostics of Ryazan State Medical University named after Academician I.P. Pavlov of the Ministry of Health of Russia.
https://orcid.org/0000-0002-1687-332X.
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