Novosti
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This journal is indexed in Scopus |
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Year 2017 Vol. 25 No 5
SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY
O.Y. POPADYUK
ASSESSMENT OF DEGRADABLE AND MECHANICAL PROPERTIES OF NANO-CONTAINING WOUND HEALING POLYMER MATERIALS
SHEI “Ivano-Frankivsk National Medical University”, Ivano-Frankivsk,
Ukraine
Objectives. To evaluate the mechanical and degrading properties of nano-containing wound-healing polymer materials in the study in vitro.
Methods. The bio-polymer bases in the form of films were used in the research in which nano-oxides zinc (ZnO), magnesium nano-oxides (MgO) and pyrogenic silica (SiO2) in various concentrations were introduced. The degradation, relative elongation at break, tensile strength in tensile testing machine, density and Shore hardness, and their swelling properties of the studied bio-polymers were investigated in vitro.
Results. The study has shown that the introduction into the polymeric base of 1% solution of silicon oxide slightly increases the film strength, while an increase in its content up to 5% slightly reduces it. The same pattern is observed in the case of the introduction of zinc and magnesium into the film. After 1 day of the film exposure in water, tensile strength could not be determined as the films degraded and was destroyed while fixing the studied materials in the tensile machine. This demonstrates the ability of the film to degrade being in contact with the liquid. Conducted at 36°C study shows that the strength of all films is sharply reduced and is within the error of the tensile machine. Investigation of the density of synthesized films has shown that films with 1% content of zinc nanooxides and silicon oxide have a high density, which correlates with the breaking strength. Determining the degree of film swelling has shown a high capacity for swelling in the films without nanooxides of zinc and somewhat decreased degree of swelling in case of its presence.
Conclusions. Our study has shown that the properties of bio-degradable polymeric materials depend on concentration of active drugs that are introduced and their degradation properties can provide drug delivery of the medication to the affected region.
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76018, Ukraine,
Ivano-Frankivsk, Galitskaya str., 2,
SHEI “Ivano-Frankivsk National Medical University”,
Department of General Surgery,
tel.: +380 34 252-82-32, E-mail: popadyukoleg@ukr.net Oleg Y. Popadyuk
Popadyuk O.Y., PhD, Associate Professor of the General Surgery Department of SHEE “Ivano-Frankivsk National Medical University”.
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