Novosti
Khirurgii

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Year 2017 Vol. 25 No 5

REVIEWS

Î.À. GOVORUKHINA

CURRENT DIAGNOSIS AND TREATMENT OF HIRSCHSPRUNG’S DISEASE IN CHILDREN

SE “Republican Scientific and Practical Center of Pediatric Surgery”, Minsk,
The Republic of Belarus

The paper reviews recent studies that evaluate the present-day concept concerning Hirschsprung’s disease in children as well as current diagnostic and treatment methods of this pathology.
Hirschsprung’s disease is a relatively common disease in the pediatric surgery. The literature analysis has shown that if the pathogenesis of the disease is no longer considered controversial entity, the application of new methods of examination and surgical treatment still remains complex and ambiguous. The use of one or another method of diagnosis and treatment is thought to be determined mainly by the possibilities and preferences of medical establishment. At the same time, the functional results of surgical treatment leave much to be desired due to the absence of clearly defined terms for surgical correction of the defect, as well as the unresolved issues of choice of operative treatment method appropriated for each specific child.
The analysis of the literature data has shown the possibility of solving these problems by developing a rational program of examination, taking into account all existing complications and determining the appropriate treatment tactics.
Radical one-stage surgical treatment of Hirschsprung’s disease with the use of minimally invasive methods is becoming more widespread. Current surgical methods for treating Hirschsprung’s disease in infant and young children are essential in reducing morbidity and mortality associated with this disease.

Keywords: Hirschsprung’s disease, agangliosis, colon, enterocolitis, transanal endorectal pull-through, postoperative complications, mortality
p. 510-517 of the original issue
References
  1. Somme S, Langer JC. Primary versus staged pull-through for the treatment of Hirschsprung disease. Semin Pediatr Surg. 2004 Nov;13(4):249-55.
  2. Gariepy CE. Intestinal motility disorders and development of the enteric nervous system. Pediatr Res. 2001 May;49(5):605-13.
  3. Tam PK, Garcia-Barcelo M. Molecular genetics of Hirschsprung’s disease. Semin Pediatr Surg. 2004 Nov;13(4):236-48.
  4. Amiel J, Sproat-Emison E, Garcia-Barcelo M, Lantieri F, Burzynski G, Borrego S, et al. Hirschsprung Disease Consortium. Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet. 2008 Jan;45(1):1-14.
  5. Kim JH, Yoon KO, Kim JK, Kim JW, Lee SK, Kong SY, et al. Novel mutations of RET gene in Korean patients with sporadic Hirschsprung’s disease. J Pediatr Surg. 2006 Jul;41(7):1250-54.
  6. Swenson O. Hirschsprung’s disease: a review. Pediatrics. 2002 May; 109(Is 5):914-18.
  7. Holschneider AM, Puri P, eds. Hirschsprung’s Disease and Allied Disorders. 3rd ed. New York, NY: Springer; 2008. 414 p.
  8. Dasgupta R, Langer JC. Hirschsprung disease. Curr Probl Surg. 2004;41(12):942-88.
  9. Yan Z, Poroyko V, Gu S, Zhang Z, Pan L, Wang J, et al. Characterization of the intestinal microbiome of Hirschsprung’s disease with and without enterocolitis. Biochem Biophys Res Commun. 2014 Mar 7;445(2):269-74. doi: 10.1016/j.bbrc.2014.01.104.
  10. Diamond IR, Casadiego G, Traubici J, Langer JC, Wales PW. The contrast enema for Hirschsprung disease: predictors of a false-positive result. J Pediatr Surg. 2007 May;42(5):792-95.
  11. De Lorijn F, Reitsma JB, Voskuijl WP, Aronson DC, Ten Kate FJ, Smets AM, et al. Diagnosis of Hirschsprung’s disease: a prospective, comparative accuracy study of common tests. J Pediatr. 2005 Jun;146(6):787-92.
  12. Garcia R, Arcement C, Hormaza L, Haymon ML, Ward K, Velasco C, et al. Use of the recto-sigmoid index to diagnose Hirschsprung’s disease. Clin Pediatr (Phila). 2007 Jan;46(1):59-63.
  13. Proctor ML, Traubici J, Langer JC, Gibbs DL, Ein SH, Daneman A, et al. Correlation between radiographic transition zone and level of aganglionosis in Hirschsprung’s disease: Implications for surgical approach. J Pediatr Surg. 2003 May;38(5):775-78.
  14. Pratap A, Gupta DK, Tiwari A, Sinha AK, Bhatta N, Singh SN, et al. Application of a plain abdominal radiograph transition zone (PARTZ) in Hirschsprung’s disease. BMC Pediatrics. 2007;7:5. doi: 10.1186/1471-2431-7-5.
  15. De la Torre L, Santos k. Hirschsprung disease. Evaluation of calretinin and S-100 as ancillary methods for the diagnosis of aganglionosis in rectal biopsies. Acta Pediatr Mex. 2012 Sep-Oct;33(5):246-51.
  16. Holland SK, Ramalingam P, Podolsky RH, Reid-Nicholson MD, Lee JR. Calretinin immunostaining as an adjunct in the diagnosis of Hirschsprung disease. Ann Diagn Pathol. 2011 Oct;15(5):323-28. doi: 10.1016/j.anndiagpath.2011.02.010.
  17. Spitz L, Coran AG, eds. Operative Pediatric Surgery. 6th ed. London: Hodder Arnold; 2007. 1060 p.
  18. Nasr A, Langer JC. Evolution of the technique in the transanal pull-through for Hirschsprung’s disease: effect on outcome. J Pediatr Surg. 2007 Jan;42(1):36-9; discussion 39-40.
  19. Georgeson KE, Robertson DJ. Laparoscopic-assisted approaches for the definitive surgery for Hirschsprung’s disease. Semin Pediatr Surg. 2004 Nov;13(4):256-62.
  20. Cobellis G, Noviello C, Cruccetti A, Romano M, Mastroianni L, Amici G, et al. Staged laparoscopic-assisted endorectal pull-through for long segment Hirschprung’s disease and total colonic aganglionosis. Minerva Pediatr. 2011 Jun;63(3):163-67.
  21. Bradnock TJ, Walker GM. Evolution in the management of Hirschsprung’s disease in the UK and Ireland: a national survey of practice revisited. Ann R Coll Surg Engl. 2011 Jan; 93(1): 34-38. doi: 10.1308/003588410X12771863936846.
  22. Huang EY, Tolley EA, Blakely ML, Langham MR. Changes in hospital utilization and management of Hirschsprung disease: analysis using the kids’ inpatient database. Ann Surg. 2013 Feb;257(2):371-7. doi: 10.1097/SLA.0b013e31827ee976.
  23. Niramis R, Watanatittan S, Anuntkosol M, Buranakijcharoen V, Rattanasuwan T, Tongsin A, et al. Quality of life of patients with Hirschsprung’s disease at 5 - 20 years post pull-through operations. Eur J Pediatr Surg. 2008 Feb;18(1):38-43. doi: 10.1055/s-2008-1038325.
Address for correspondence:
220013, Republic of Belarus,
Minsk, Nezavisimost Ave., 64,
SI «Republican Scientific
and Practical Center for Pediatric Surgery»,
Tel.: +375 29 1696581,
E-mail: govorukhina@mail.ru
Olga A. Govorukhina
Information about the authors:
Govorukhina O.A. PhD, Ass. Professor, Head of Department of Surgical Diseases N 2, SE “Republican Scientific and Practical Center of Pediatric Surgery”.
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