Novosti
Khirurgii
This journal is
indexed in Scopus









Year 2015 Vol. 23 No 3

ONCOLOGY

DOI: http://dx.doi.org/10.18484/2305-0047.2015.3.326   |  

O.S. OLIFIROVA, S.V. KNALYAN

THE ROLE OF TUMOR MARKERS FOR THE DIFFERENTIAL DIAGNOSIS OF NODULAR THYROID NODULES

SBEE HPE "Amur State Medical Academy",
Blagoveshchensk,
The Russian Federation

Objectives. To assess the diagnostic significance of tumor markers of galectin-3, thyroglobulin (TG), carcinoembryonic antigen (CEA) and human chorionic gonadotropin (HCG) in the blood serum and aspirate washout in patients with nodular thyroid disease.
Methods. The study involved 80 patients with nodular thyroid diseases. Highly differentiated cancer was registered in 37 patients and benign nodular disease in 43 ones. In the preoperative period tumor markers (galectin-3, thyroglobulin, CEA and HCG) were determined by enzyme immunoassay in blood serum and aspirate washout obtained by fine-needle aspiration biopsy of thyroid nodules.
Results. In highly differentiated cancer of thyroid gland a significant increase of galectin-3 and CEA in the blood serum galectin-3 and thyroglobulin in aspirate washout were found in comparison with benign nodular thyroid disease. The sensitivity and specificity of galectin-3 in blood serum were 51,4% and 95,3%; galectin-3 in aspirate washout 59,7% and 90,7%; TG in aspirate washout 64,9% and 93%; serum CEA 66,7% and 91,3%, respectively.
Conclusion. Study of tumor markers in the blood serum (galectin-3, CEA) and aspirate washout (galectin-3, thyroglobulin) as the additional parameters with standard methods allows increasing the efficiency of diagnosis of nodular thyroid diseases. Due to the determination of galectin-3 in the blood serum the sensitivity in differentiated diagnosis of thyroid cancer has increased from 83,8% up to 92%, galectin-3 in thyroid aspirate washout - up to 97, 3%, TG thyroid aspirate washout up to 89,2%, CEA in blood serum up to 94,4%.

Keywords: diagnostics, tumor markers, thyroid nodules, highly-differentiated thyroid cancer, enzyme immunoassay, thyroglobulin, galectin-3
p. 326-331 of the original issue
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Address for correspondence:
675000, Rossiyskaya Federatsiya,
g. Blagoveschensk, ul. Gorkogo, d. 95,
GBOU VPO "Amurskaya gosudarstvennaya meditsinskaya akademiya",
fakultet poslediplomnogo obrazovaniya,
kafedra khirurgicheskih bolezney,
tel. mob: 7 914 554-46-52,
e-mail: olif.oc@mail.ru,
Olifirova Olga Stepanovna
Information about the authors:
Olifirova O.S. MD, an associate professor, a head of the surgical diseases chair of the advanced training faculty of SBEE HPE "Amur State Medical Academy".
Knalyan S.V. A post-graduate student of the surgical diseases chair of the advanced training faculty of SBEE HPE "Amur State Medical Academy".
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