Year 2011 Vol. 19 No 2

HYPOTHESIS

LEVIN M.D., DEGTYAROV I.G.

PERSPECTIVES OF THE FUNCTIONAL CONSTIPATION TREATMENT IN CHILDREN

Here we offer a hypothesis of the disease, based on literature review as well as our analysis of 280 pediatric patients with functional constipation, who were examined at the Byelorussian Pediatric Surgical Center. Primary delay of defecation leads to enlargement of fecal masses. This in turn makes it difficult to have a normal bowel movement and causes further delay of defecation which leads to further increase in fecal mass and so on. If this vicious cycle is not broken within first several weeks of symptoms, rectum will become stretched. Earlier we described methods of precise evaluation of the size of rectum and differentiation among 3 degrees of puborectal muscle tone weakening. The muscle responsible for anal elevation during defecation fails to open anal canal. Gradually, pelvic floor muscles become more and more rigid. As a result, there is disproportion between large width of fecal masses and decreased ability of the anal canal to pass fecal masses. Chronic intestinal impaction promotes development of colitis and irritable bowel syndrome. Treatment has to take in consideration decreases opening of the rectum and restoration of the ability of anal canal to pass fecal masses. Methods of treatment (conventional therapy, anal stretching, sphincterometry of the inner sphincter, botuline toxin injection, biofeedback-therapy and sacral nerve electro stimulation) and their duration must be chosen base on the megacolon degree and symptoms of anal canal damage).

Keywords: functional constipation, pathological physiology, anal canal, megacolon, megarectum, children, irritable bowel syndrome, treatment
p. 113 – 124 of the original issue
References
  1. van der Berg, M. M. Epidemiology of childhood constipation: a systematic review / M. M. van der Berg, M. A. Benninga, C. Di Lorenzo // Am. J. Gastroenterol. – 2006. – Vol. 101, N 10. – P. 2401-2409.
  2. Outcome of functional constipation in childhood: a 10-year follow-up study / L. Michaud [et al.] // Clin. Pediat. (Phila). – 2009. – Vol. 48, N 1. – P. 26-31.
  3. Health-related quality of life in young adults with symptoms of constipation continuing from childhood into adulthood / M. E. J. Bongers [et al.] // Health Qual. Life Outcomes. – 2009. – Vol. 2, N 7. – P. 20.
  4. Management principles of organic causes of childhood constipation / N. Tobias [et al.] // J. Pediatr. Health Care. – 2008. – Vol. 22, N 1. – P. 12-23.
  5. Childhood functional gastrointestinal disorders: neonate/toddler / P. E. Hyman [et al.] // Gastroenterology. – 2006. – Vol. 130, N 5. – P. 1519-1526.
  6. Wong, P. K. W. How to deal with chronic constipation. A stepwise method of establishing and treating the source of the problem / P. K. W. Wong, S. H. Kadakia // Postgrad. Med. – 1999. – Vol. 106, N 6. – P. 199-110.
  7. Chang, S. Polyethylene glycol 3350 without electrolytes for treatment childhood constipation / S. Chang, A. Cheng, R. D. Goldman // Can. Fam. Physician. – 2009. – Vol. 55, N 5. – P. 481-482.
  8. Candy, D. C. Treatment of faecal impaction with polyethelene glycol plus electrolytes (PGE + E) followed by a double-blind comparison of PEG + E versus lactulose as maintenance therapy / D. C. Candy, D. Edwars, M. D. Geraint // Pediatr. Gastroenterol. Nutr. – 2006. – Vol. 43, N 1. – P. 65-70.
  9. Novel and alternative therapies for childhood constipation / P. Coccorullo [et al.] // Pediatr. Gastroenterol. Nutr. – 2009. – Vol. 48. – Suppl. 2. – S104-106.
  10. Recommendation on chronic constipation (including constipation associated with irritable bowel syndrome) treatment / P. Pare [et al.] // Can. J. Gastroenterol. – 2007. – Vol. 21. – Suppl. B. – P. 3B-22B.
  11. Clayden, G. S. Investigation and management of long-standing chronic constipation in childhood / G. S. Clayden, J. O. H. Lawson // Arch. Dis. Child. – 1976. – Vol. 51, N 12. – P. 918-923.
  12. Chiarioni, G. Biofeedback therapy for dyssynergic defecation / G. Chiarioni, S. Heymen, W. E.Whitehead // World J. Gastroenterol. – 2006. – Vol. 28, N 12 (44). – P. 7069-7774.
  13. Palsson, O. S. Biofeedback treatment for functional anorectal disorders: a comprehensive efficacy review / O. S. Palsson, S. Heymen, W. E. Whitehead // Appl. Psychophysiol. Biofeedback. – 2004. – Vol. 29, N 3. – P. 153-174.
  14. Chiarini, G. Biofeedback therapy for dyssynergic defecation / G. Chiarini, S. Heymen, W. E. Whitehead // World Gastroenterol. – 2006. – Vol. 28, N 12 (44). – P. 7069-7074.
  15. Long-term follow-up of medically treated childhood constipation / J. L Sutphen [et al.] // Clin. Pediatr. Phila. – 1995. – Vol. 34, N 11. – P. 576-580.
  16. Whitehead, W. E. Functional anorectal disorders. // Semin. Gastrointest. Dis. – 1996. – Vol. 7, N 4. – P. 230-236.
  17. Способ диагностики заболеваний толстой кишки: а. с. 944540 СССР / М. Д. Левин, В. А. Катько; опубл. БИ. 21. 1982.
  18. Левин, М. Д. К рентгенологической анатомии толстой и прямой кишок у детей / М. Д. Левин // Вестн. рентгенологии. – 1985. – № 2. – С. 40-45.
  19. Левин, М. Д. Рентгенофункциональные исследования актов удержания и дефекации / М. Д. Левин // Педиатрия. – 1983. – № 2. – С. 49-52.
  20. Левин, М. Д. Анатомия и физиология аноректальной зоны. Гипотеза удержания кала и дефекации / М. Д. Левин, В. В. Троян // Новости хирургии. – 2009. – № 2. – С. 105-118.
  21. Левин, М. Д. Функциональный мегаколон у детей / М. Д. Левин // Педиатрия. – 1989. – № 8. – С. 22-27.
  22. Мишарев, О. С. Функциональные и рентгенологические исследования аноректальной зоны при заболеваниях кишечника / О. С. Мишарев, М. Д. Левин // Хирургия. – 1984. – № 12. – С. 78-82.
  23. Loening-Baucke, V. A. Abnormal rectoanal function in children recovered from chronic constipation and encopresis / V. A. Loening-Baucke // Gastroenterol. – 1984. – Vol. 87, N 6. – P. 1299-1304.
  24. Biofeedback training for constipation and children / J. Weber [et al.] // Dis. Colon. Rectum. – 1987. – Vol. 30, N 11. – P. 844-846.
  25. Rectal compliance and rectal sensation in constipated adolescents, recovered adolescents and healthy / M. M. van den Berg [et al.] // Gut. – 2008. – Vol. 57, N 5. – P. 599-603.
  26. New insight into rectal function in pediatric defecation disorders: disturbed rectal compliance is an essential mechanism in pediatric constipation / W. P. Voskuijl [et al.] // J. Pediatr. – 2006. – Vol. 148, N 1. – P. 62-67.
  27. Li, Z. H. Functional constipation in children: investigation and management of anorectal motility / Z. H. Li, M. Dong, Z. F. Wang // World J. Pediatr. – 2008, N 4, N 1. – P. 4508.
  28. Rao, S. S. Obstructive defecation: failure of rectoanal coordination / S. S. Rao, K. D. Welcher, J. S. Leistikow // Am. J. Gastroenterol. – 1998. – Vol. 93, N 7. – P. 1019-1020.
  29. Transabdominal ultrasound of rectum as a diagnostic tool in childhood constipation / I. M. Joensson [et al.] // J. Urol. – 2008. – Vol. 179, N 5. – P. 1997-2002.
  30. Patterns of anismus and the relation to biofeedback therapy / U. C. Park [et al.] // Dis. Colon. Rectum. – 1996. – Vol. 39, N 7. – P. 768-773.
  31. Hosie, G. P. Idiopathic constipation in childhood is associated with thickening of the internal anal sphincter / G. P. Hosie, L. Spitz // J. Pediatr. Surg. – 1997. – Vol. 32, N 7. – P. 1041-1043.
  32. Shafic, A. Idiopathic oligofecorrhea: a clinicopathologic entity -pathogenesis and treatment / A. Shafic // Digestion. – 1991. – Vol. 48, N 1. – P. 51-58.
  33. Shafik, A. Constipation – some provocative thoughts / A. Shafik // J. Clin. Gastroenterol. – 1991. – Vol. 13, N 3. – P. 259-267.
  34. The spastic floor syndrome: its diagnosis and treatment / P. Carbognani [et al.] // Ann. Ital. Chir. – 1992. – Vol. 63, N 1. – P. 69-73.
  35. Левин, М. Д. Патологическая физиология, диагностка и перспективы лечения низких свищевых форм неперфорированного ануса / М. Д. Левин, В. В. Троян // Новости хирургии. – 2008. – Т. 16, № 4. – С. 65-76.
  36. Левин, М. Д. Рентгенофункциональные исследования при эктопии анального канала у детей / М. Д. Левин // Вестн. рентгенологии. – 1989. – № 5. – С. 10-16.
  37. Никифоров, А. Н. // Вестн хирургии / А. Н. Никифоров, М. Д. Левин, И. Ф. Абу-Варда. – 1990. – № 8. – С. 78-82.
  38. Левин, М. Д. Хронический колит у детей / М. Д. Левин // Педиатрия. – 1989. – № 9. – С. 69-73.
  39. Smith, E. I. Prestenotic enteritis and enterocolitis in children: Description of a syndrome and review of five cases / E. I. Smith, C. C. Gill // South Med. J. – 1975. – Vol. 68, N 4. – P. 426-427.
  40. Irritable bowel syndrome in children / J. Schmitz [et al.] // Gastroenterol. Clin. Biol. – 1990. – Vol. 14, N 5. – P. 54-57.
  41. S. Khan [et al.] Long-term outcome of functional childhood constipation // Dig. Dis. Sci. – 2007. – Vol. 52, N 1. – P. 64-69.
  42. Familial aggregation in constipated subjects in a tertiary referral center / A. O. Chan [et al.] // Am. J. Gastroenterol. – 2007. – Vol. 102, N 1. – P. 149-152.
  43. Idiopathic slow transit constipation is rare. But delayed passage of meconium is common in the constipation clinic / C. D. Kroaker [et al.] // Pediatr. Surg. Int. – 2007. – Vol. 23, N 12. – P. 1153-1159.
  44. Misra, S. Chronic constipation in overweight children / S. Misra, A. Lee, K. Gensel // J. Parenter. Enter Nutr. – 2006. – Vol. 30, N 2. – P. 81-84.
  45. Ludvigsson, J. F. Abis Study Group. Epidemiological study of constipation and other gastrointestinal symptoms in 8000 children / J. F. Ludvigsson // Acta Paediatr. – 2006. – Vol. 95, N 5. – P. 573-580.
  46. Никифоров, А. Н. Состояние анального канала у стариков с хроническим запором. (Рентгенологическое исследование) / А. Н. Никифоров, М. Д. Левин // Мед. панорама. – 2006. – № 6. – C. 4-7.
  47. Treatment of puborectalis syndrome with progressive anal dilation / G. Maria [et al.] // Dis. Colon. Rectum. – 1997. – Vol. 40, N 1. – P. 89-92.
  48. Klug, W. Behanduung der Analfissur durch Eigenbougierung mit dem Analdehner / W. Klug, H. G. Knoch // Z. arztl. Fortbild. – 1989. – Vol. 83. – P. 1261-1263.
  49. R. van Ginkel [et all.] The effect of anorectal manometry on the outcome of treatment in severe childhood constipation: randomized, controlled trial // Pediatrics. – 2001. – Vol. 108, N 1. – P. 9.
  50. Biggs, W.S. Evaluation and treatment of constipation in infants and children / W. S. Biggs, W. H. Dery // Am. Fam. Physician. – 2006. – Vol. 73, N 3. – P. 469-477.
  51. Initial North American experience with botulinum toxin A for treatment of anismus / J.S. Joo [et al.] // Dis. Colon. Rectum. – 1996. – Vol. 39, N 10. – P. 1107-1111.
  52. Internal anal sphincter achalasia in children: clinical characteristics and treatment with Clostridium botulinum toxin / P. Ciamarra [et al.] // J. Pediatr. Gastroenterol. Nutr. – 2003. – Vol. 37, N 3. – P. 315-319.
  53. Effect of electrical stimulation in constipated patients with impaired rectal sensation / H. S. Chang [et al.] // Int. J. Colorectal. Dis. – 2003. – Vol. 18, N 5. – P. 433-438.
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