Year 2008 Vol. 16 No 2

UROLOGY

SAMARA MUHAMMAD ALI IBRAGIM

INFLUENCE OF CONSERVATIVE AND OPERATIVE TREATMENT ON THE METABOLIC STATUS OF THE PATIENTS WITH BENIGN HYPERPLASIA OF THE PROSTATE

The biochemical indexes of the blood serum of 240 patients with benign hyperplasia of the prostate and of 33 patients without benign hyperplasia of the prostate, undergoing treatment in the urological clinic of Vitebsk state medical university on the basis of the regional clinical hospital during the period of 2005-2008 have been analyzed.
The obtained data show that treatment of the 1st stage patients with doxazosin is accompanied by the steady proatherogenic shift of the cholesterol blood profile; hyperproteinemia and hyperglycemia are observed. Treatment of the 1st stage patients with doxazosin and finasteride affects the metabolism favorably: decrease of the activity in the blood of the intracellular ferments takes place on the ground of the proatherogenic shift. Surgical treatment of the 2nd stage patients is accompanied by the increase of cholesterol HDL level, by hyperglycemia. 11 months after the surgical treatment of the 3rd stage patients, there were no any changes of lipid profile in comparison with the pre-operative indexes: decrease of the total cholesterol, cholesterol HDL level was marked, and 11 months after the surgical treatment the increase of cholesterol LDL was marked.

Keywords: benign hyperplasia of the prostate, metabolic status.
p. 88 – 97 of the original issue
References
  1. McNeal,J.E. Normal histology of the prostate / J. E.McNeal // Am. J. Surg. Pathol. – 1988. – Vol. 12. – P. 619-633.
  2. Лукьянов, И.В. Доброкачественная гиперплазия предстательной железы. Современные возможности лечения / И.В. Лукьянов // Русский Медицинский Журнал. – 2004. – Т. 12, №14.
  3. Lekili, M. Serum lipid levels in benign prostatic hyperplasia / M. Lekili , B.S.Uyanik, C. Bьyьksu // World J. Urol. – 2006. – N24(2). – P. 210-213 .
  4. Доброкачественная гиперплазия предстательной железы [Электронный ресурс] / Н. А.Лопаткин [и др. ]. – НИИ урологии Минздрава РФ, 2000.
  5. Watanabe,H. Natural history of benign hypertrophy / H.Watanabe / H. Watanabe // Ultrasound Med. Biol. – 1986. – Vol. 12. – P. 567–571.
  6. Vermeulen,A. Testosteron secretion and metabolism in male senescence / A.Vermeulen, R.Rubens, L.Verdonk // J. Clinical Endocrinol. Metabolism. – 1972. Vol. 34. – P. 730-735.
  7. Пытель,Ю.А. Этиология и патогенез гиперплазии предстательной железы / Ю.А.Пытель, Винаров А. З. // Доброкачественная гиперплазия предстательной железы / под ред. Н. А. Лопаткина. – М., 1997. – С. 19-30.
  8. Гориловский, Л.М. Современные представления о диагностике и лечении доброкачественной гиперплазии предстательной железы / Л.М. Гориловский // РМЖ. –1997. – Т. 5, №23. – С. 274-290.
  9. Lekili,M. Serum lipid levels in benign prostatic hyperplasia / M.Lekili , B.S.Uyanik , C. Bьyьksu // World J. Urol. – 2006. – Vol. 24, N2. – P. 210-213.
  10. 10. Weisser,H. Lipid composition in epithelium and stroma of human benign prostatic hyperplasia / H.Weisser, M. Krieg // Prostate. –1997. – Vol. 30, N1. – P. 41-46.
  11. Афифи, А.Статистический анализ. Подход с использованием ЭВМ / А. Афифи, С. Эйзен. – М.: Мир, 1982. – 220 с.
Contacts | ©Vitebsk State Medical University, 2007-2023